Jetsun Sherab Senge, an outstanding scholar of the great tantric treatises, was one of Tsongkhapa’s six closest disciples.  Tsongkhapa instructed him to propagate his tantric teachings and gave him a skullcup full of nectar, a bronze statue of Guhyasamaja Tantra, a copy of the two great commentaries on it as well as a mask and costume of Yama.  He thereby made him successor to his tantric tradition and asked him to go to Tsang to spread the teaching of the tantras, prediction that he would find good students there. 

On arriving there Jetsun Sherab Senge first performed a Vajrabhairava retreat during which he was served by a spirit woman.  He then established Se Gyupa Tantric Monastery and a little later established Gyudme Monastery in Lhasa.  He saw to it that the tradition of tantric teachings flourished in both monasteries.